The article focuses on contemporary methodologies for laser-based, non-invasive reconstruction of biological tissues. It examines the mechanisms of laser-tissue interaction, including photothermal processes and the formation of new molecular bonds. A range of laser systems – neodymium-doped yttriumaluminum garnet laser (Nd:YAG laser), carbon dioxide laser (CO2 laser), diode and their applications in vascular, micro- and plastic surgery are analyzed. The analysis is further enriched by a discussion of bioorganic solders, such as albumin and indocyanine green, and nanomaterials that have been shown to enhance bond strength and reduce thermal damage. Examples of successful applications of the technology for vascular and nerve repair, wound sealing, and plastic surgery are provided. Finally, future prospects are highlighted, including temperature control systems and personalized approaches. The text emphasizes the potential of laser methods as a minimally invasive alternative to traditional surgery.

This article describes methods of nonlinear physics related to recurrent analysis that may be useful in studying the effect of posttraumatic stress disorder on sleep disorders. Traditional pharmacological and psychotherapeutic approaches widely used to treat post-traumatic stress disorder require longterm and painstaking work, combining the joint efforts of clinical specialists and the patient. The versatility and variability of the clinical picture of this disease makes the diagnosis and treatment of post-traumatic stress disorder syndromes particularly difficult. In particular, only in International Classification of Diseases 11th Revision was complex post-traumatic stress disorder isolated from the general group of dissociative disorders. However, one of the few unifying characteristics for such patients is significant disruption of night sleep. Currently, mathematical methods, pumped from nonlinear physics, are often used to analyze physiological signals and assess the condition of patients with various diseases, including depression, chronic migraines, and apnea syndrome. However, recurrent analysis has not been used to date in the study of post-traumatic stress disorder. We are confident, based on the successful application of this method to the study of patients with migraines, orthodontic disorders, and sleep disorders, that this is a major omission and scientists working on the problem of post-traumatic stress disorder should pay close attention to the methods proposed in this article for a comprehensive study of the problem. Careful application of the proposed methods will undoubtedly contribute to the study of the effect of various psychiatric diseases on sleep, including posttraumatic stress disorder, and will help to develop more advanced methods of gentle rehabilitation.

Conventional photosensitizing agents have inherent limitations regarding their effectiveness, selectivity, and potential adverse effects, which can hinder their clinical application in oncological practices. This study delves into innovative strategies aimed at the development of advanced photosensitizers that promise improved performance for clinical use. We present a comprehensive analysis of a range of molecules with diverse chemical structures, including novel nanomaterials and conjugated systems. These compounds demonstrate remarkable photostability and possess a high capacity for selectively targeting tumor tissues, which is crucial for enhancing therapeutic outcomes. In addition to discussing the improved properties of these next-generation photosensitizers, we provide an in-depth examination of their mechanisms of action, highlighting how they induce cytotoxic effects in cancer cells while minimizing harm to adjacent healthy tissues. The potential toxicity of these compounds has been scrutinized, considering both acute and long-term effects, with a focus on strategies to mitigate adverse side effects. Our research advocates for the importance of continued investigation into the development and optimization of photosensitizers, emphasizing their multi-disciplinary applications. By integrating insights from chemistry, pharmacology, and oncology, we aim to increase the overall effectiveness of photodynamic therapy. Furthermore, we explore the potential of these agents to extend their applicability beyond traditional treatment settings, suggesting their integration with other therapeutic modalities, such as chemotherapy and radiotherapy, which could lead to synergistic effects and significantly improve patient outcomes in cancer treatment.

This study highlights data on the increasing role of incretins in interdisciplinary therapy for endocrinopathies, particularly glucagon-like peptide-1 (GLP-1), which affects carbohydrate metabolism, insulin secretion, and other metabolic processes. The mechanisms of secretion, biological activity, and degradation of these peptides are described, along with their role in regulating appetite, gastrointestinal motility, and carbohydrate metabolism. This information allows for a comprehensive understanding of the effects of synthetic GLP-1 analogs. We also explore modern approaches to treating obesity in children and adolescents, including the use of GLP-1 receptor agonists such as liraglutide. It presents the results of a clinical study confirming the effectiveness and safety of liraglutide in reducing body weight and improving metabolic indicators in children with obesity. It is shown that liraglutide not only promotes weight loss but also has cardioprotective effects, improving lipid profiles and reducing blood pressure. The efficacy of liraglutide in children aged 12–18 with obesity was amount to 43.3 - 76.5%. The prevalence of hypertension in obese children decreased from 30.9% to 4.8%, carbohydrate metabolism disorders from 41.1% to 19.4%, dyslipidemia from 20.6% to 9.7%. Liraglutide reduces the risk of major adverse cardiovascular events by 13–22% in patients with type 2 diabetes and high cardiovascular risk. This effect is attributed to moderate blood pressure reduction, improved lipid profiles, enhanced endothelial function, and anti-inflammatory and antioxidant actions. Additionally, the article discusses the prospects for using GLP-1 receptor agonists in cardiology, including their ability to reduce the risk of cardiovascular events in patients with type 2 diabetes and obesity.

Myocardial contusion is a serious consequence of blunt thoracic trauma, most commonly resulting from traffic accidents, falls, sports injuries, and combatrelated events. It is associated with impaired myocardial contractility, fibrosis, and systemic inflammation, and carries a high risk of complications, with mortality rates reaching up to 10%. Despite advances in understanding the pathogenesis, the development of effective therapeutic strategies remains a key priority in experimental cardiology. 

A promising direction involves the development of targeted approaches that address both myocardial injury and the optimization of adaptive responses. The first aspect focuses on counteracting bioenergetic hypoxia, restoring energy and ionic homeostasis, suppressing secondary damage in the context of inflammation, and regulating apoptosis and autophagy. The second aspect targets the modulation of stress-activating and stress-limiting systems, including tissue-level adaptation mechanisms.

Particular attention has been given to cardioprotective agents, which have demonstrated efficacy in ischemic heart disease, myocardial infarction, and ischemia–reperfusion injury. However, their impact on post-traumatic myocardial remodeling remains insufficiently explored. Phytopreparations from the Chinese Pharmacopoeia, characterized by multitarget activity on key pathological processes — such as bioenergetic deficiency, oxidative stress, and dysregulation of cellular homeostasis — may offer a viable alternative. Integrated strategies combining anti-inflammatory effects, metabolic support, and control of fibrogenesis may enhance therapeutic outcomes.

Further research is necessary to assess the synergistic interactions of individual components, dose-dependent responses, and the long-term impact on myocardial structure and function. Multimodal approaches may improve therapeutic efficacy and help overcome the limitations of monotherapy, opening new avenues for the management of post-traumatic cardiac complications.