ejolsThe Eurasian Journal of Life SciencesЕвразийский журнал наук о жизни3033-54933033-6031Сеченовский Университет10.47093/3033-5493.2025.1.1.53-72ejols-7Research ArticleСтатьиTreatment of cardiac contusion: experimental basis for pathogenetic therapy and emerging approaches in cardioprotectionЛечение ушиба сердца: экспериментальные основы патогенетической терапии и новые подходы к кардиопротекцииhttps://orcid.org/0000-0002-6775-323XЗолотовА. Н.ZolotovA. N.

Александр Николаевич Золотов, канд. мед. наук, доцент, старший научный сотрудник центральной научно-исследовательской лаборатории, доцент кафедры патофизиологии

644099, г. Омск, Ул. Ленина, д.12

Alexander N. Zolotov, PhD, Associate Professor, Senior Researcher of the Central Research Laboratory, Associate Professor of the Department of Pathophysiology

str. Lenina, 12, Omsk, 644099

zolotov@omgmu.ruhttps://orcid.org/0009-0009-2846-6711ЛиЦ.LiJ.

Цзяминь Ли, профессор, заместитель руководителя департамента

150088, Хэйлунцзян, г. Харбин, ул. Баоцзянь, д.157

Jiamin Li, PhD, Professor, Deputy Director of the Office

157 Baojian Rd, Nangang, Harbin, 150088, Heilongjiang

https://orcid.org/0000-0002-7243-6968ВанН.WangN.

Нин Ван, профессор, заместитель директора

150088, пров. Хэйлунцзян, г. Харбин, ул. Баоцзянь, д.157

Ning Wang, PhD, Professor, Deputy director

157 Baojian Rd, Nangang, Harbin, 150088, Heilongjiang

https://orcid.org/0000-0003-0063-3433ПриймакА. Б.PriymakA. B.

Антон Борисович Приймак, канд. мед. наук, ассистент кафедры патофизиологии

644099, г. Омск, ул. Ленина, д.1

Anton B. Priymak, PhD, Assistant of the Department of Pathophysiology

str. Lenina, 12, Omsk, 644099

https://orcid.org/0000-0001-6110-3933КорпачеваО. В.KorpachevaO. V.

Ольга Валентиновна Корпачева, д-р. мед. наук, профессор, заведующий кафедрой патофизиологии

644099, г. Омск, ул. Ленина, д.12

 

Olga V. Korpacheva, MD, DMSc, Professor, Head of the Department of Pathophysiology

str. Lenina, 12, Omsk, 644099

https://orcid.org/0000-0003-4606-3173КлючниковаЕ. И.KlyuchnikovaE. I.

Евгения Игоревна Ключникова, аспирант, ассистент кафедры патофизиологии

644099, г. Омск, ул. Ленина, д.12

Evgenia I. Klyuchnikova, PhD student, Assistant of the Department of Pathophysiology

str. Lenina, 12, Omsk, 644099

https://orcid.org/0009-0001-2096-5390ТороповА. П.ToropovA. P.

Андрей Петрович Торопов, канд. мед. наук, ассистент кафедры патофизиологии

644099, г. Омск, ул. Ленина, д.12

 

Andrei P. Toropov, PhD, Assistant of the Department of Pathophysiology

str. Lenina, 12, Omsk, 644099

Омский государственный медицинский университетOmsk State Medical UniversityХарбинский медицинский университетHarbin Medical University202501072025115372Copyright © Zolotov A.N., Li J., Wang N., Priymak A.B., Korpacheva O.V., Klyuchnikova E.I., Toropov A.P., 20252025Золотов А.Н., Ли Ц., Ван Н., Приймак А.Б., Корпачева О.В., Ключникова Е.И., Торопов А.П.Zolotov A.N., Li J., Wang N., Priymak A.B., Korpacheva O.V., Klyuchnikova E.I., Toropov A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.eajls.com/jour/article/view/7

Myocardial contusion is a serious consequence of blunt thoracic trauma, most commonly resulting from traffic accidents, falls, sports injuries, and combatrelated events. It is associated with impaired myocardial contractility, fibrosis, and systemic inflammation, and carries a high risk of complications, with mortality rates reaching up to 10%. Despite advances in understanding the pathogenesis, the development of effective therapeutic strategies remains a key priority in experimental cardiology. 

A promising direction involves the development of targeted approaches that address both myocardial injury and the optimization of adaptive responses. The first aspect focuses on counteracting bioenergetic hypoxia, restoring energy and ionic homeostasis, suppressing secondary damage in the context of inflammation, and regulating apoptosis and autophagy. The second aspect targets the modulation of stress-activating and stress-limiting systems, including tissue-level adaptation mechanisms.

Particular attention has been given to cardioprotective agents, which have demonstrated efficacy in ischemic heart disease, myocardial infarction, and ischemia–reperfusion injury. However, their impact on post-traumatic myocardial remodeling remains insufficiently explored. Phytopreparations from the Chinese Pharmacopoeia, characterized by multitarget activity on key pathological processes — such as bioenergetic deficiency, oxidative stress, and dysregulation of cellular homeostasis — may offer a viable alternative. Integrated strategies combining anti-inflammatory effects, metabolic support, and control of fibrogenesis may enhance therapeutic outcomes.

Further research is necessary to assess the synergistic interactions of individual components, dose-dependent responses, and the long-term impact on myocardial structure and function. Multimodal approaches may improve therapeutic efficacy and help overcome the limitations of monotherapy, opening new avenues for the management of post-traumatic cardiac complications.

Ушиб сердца – серьёзное последствие тупой травмы грудной клетки, чаще всего возникающее в результате дорожно-транспортных происшествий, падений, спортивных травм и в ходе боевых действий. Это состояние сопровождается нарушением сократимости миокарда, фиброзом и системным воспалением, а также высоким риском осложнений, при этом летальность может достигать 10%. Несмотря на успехи в понимании патогенеза, разработка эффективных стратегий лечения остаётся ключевым приоритетом в экспериментальной кардиологии.

Перспективным направлением является разработка таргетных подходов, направленных как на лечение повреждения миокарда, так и на оптимизацию адаптивных реакций. Первый аспект фокусируется на противодействии биоэнергетической гипоксии, восстановлении энергетического и ионного гомеостаза, подавлении вторичного повреждения в условиях воспаления и регуляции апоптоза и аутофагии. Второй аспект направлен на модуляцию стресс-активирующих и стресс-лимитирующих систем, включая механизмы адаптации на тканевом уровне. Особое внимание уделяется кардиопротекторным препаратам, продемонстрировавшим эффективность при ишемической болезни сердца, инфаркте миокарда и реперфузионном синдроме. Однако их влияние на посттравматическое ремоделирование миокарда остается недостаточно изученным. Фитопрепараты китайской фармакопеи, характеризующиеся многоцелевым действием на ключевые патологические процессы, такие как биоэнергетический дефицит, окислительный стресс и нарушение регуляции клеточного гомеостаза, могут стать достойной альтернативой. Комплексные стратегии, сочетающие противовоспалительное действие, метаболическую поддержку и контроль фиброгенеза, могут улучшить результаты терапии.

Необходимы дальнейшие исследования для оценки синергического взаимодействия отдельных компонентов, дозозависимых ответов и долгосрочного влияния на структуру и функцию миокарда. Мультимодальные подходы могут повысить терапевтическую эффективность и помочь преодолеть ограничения монотерапии, открыв тем самым новые возможности для лечения посттравматических кардиологических осложнений

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The authors declare that there are no conflicts of interest present.